What to Expect with Strattera?
Clinical Trials
Frequently Asked Questions
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What is Strattera?
(Pronounced Stra-tair-a)
Strattera is the first and only non-stimulant medication approved by the US Food and Drug Administration (FDA) for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults.
Managing ADHD With Medication
Just about everyone has trouble concentrating or paying attention in class from time to time. But for teens with attention deficit hyperactivity disorder (ADHD), symptoms like being unable to pay attention and follow instructions can cause problems at school and in many other areas of their lives. Several medicines can help to reduce ADHD symptoms.
People with ADHD often act and think a little differently. They may have trouble in school because they get distracted easily. They may feel bored all the time for no simple reason, lose things, say or do whatever is on their mind at the time without thinking, and interrupt when other people are talking.
Scientists have found that certain medicines are helpful in improving ADHD symptoms. These medicines help people with ADHD to concentrate and focus better. Methylphenidate drugs (like Concerta, Ritalin LA, Focalin XR, or Metadate CD) affect chemical signals in the central nervous system. Research suggests that this may help people with ADHD because it increases the level of neurotransmitters in the brain called dopamine and norepinephrine. Neurotransmitters are chemicals that assist in sending messages between nerve cells in the brain. In addition to pills, methylphenidate is also available in a patch, called Daytrana, that can be placed directly on the skin allowing medicine to be absorbed.
Doctors often prescribe other types of medication to help people with ADHD. Amphetamines (such as Adderall, Adderall XR, Vyvanse, Dextrostat, and Dexedrine) treat ADHD in ways similar to methylphenidate medications.
Other types of medications that are prescribed for ADHD work differently. They are not classed as stimulant medications like those mentioned above. These include atomoxetine (Strattera) and certain antidepressants (such as Wellbutrin).
Doctors work closely with their patients who have ADHD to figure out which medicine will best treat a person based on his or her symptoms, circumstances, and whether that person has any other health problems. It's not unusual for a doctor to try a couple of medicines before finding the one that works best.
Strattera is a norepinephrine reuptake inhibitor, a class of ADHD treatment that works differently from the other ADHD medications available. Strattera is available by prescription only.
What are the Benefits of Strattera?
Everyone reacts differently to medication, so finding the right treatment can take time. Getting friends and family involved in your treatment program can be helpful—they may notice positive changes before you do.
If Strattera does work for you, there are several benefits for you to discuss with your doctor as you explore treatment options.
Full-day symptom relief
Strattera provides relief from ADHD symptoms throughout the day and into the evening.
Continuous symptom improvements
While you are likely to notice improvements in ADHD symptoms by week 2, it may take up to a month to see the full therapeutic benefits of Strattera.Your system adjusts to Strattera gradually over the first month of taking it, and it can provide effective and even ADHD symptom management.
Does not cause insomnia in children and adolescents
With Strattera, there was no difference in insomnia versus sugar pill in children and adolescents.
Effective in patients with ADHD and co-existing anxiety
Strattera is clinically proven to reduce ADHD symptoms in child and adolescent patients with ADHD and anxiety, and does not induce anxiety in adult ADHD patients.
Lack of abuse potential
Strattera has not shown potential for abuse. It is a non-controlled prescription medication.
Phone-in refills
Strattera is not a controlled substance, so you can get phone-in refills between doctor visits.
Not a stimulant
If you have previous experience with stimulant medication, you might have observed an immediate impact when it took effect and also when it stopped working.You will not experience this with Strattera, since it is not a stimulant.
Free samples available from your doctor
If your doctor determines that Strattera is a good choice for you/your child, ask your doctor about receiving a free sample.
What are the Potential Side Effects of Strattera?
As with all medications, it is important to understand the possible side effects and what to expect with a medication.
Read more>>
Hear From People Who Have Tried Strattera
Listen to parents of children with ADHD and adults who have had success with Strattera.
Questions to Ask Your Healthcare Professional
Here are some important questions you may want to ask your healthcare professional about Strattera.
Clinical Trials
The safety and effectiveness of Strattera was established in six trials involving over 4,000 children, adolescents and adults.
ADHD Stimulant Medication
It has been shown in numerous studies that stimulant
medication provides significant benefit to between 70 and 80% of
children with ADHD. The most commonly prescribed medication used to
treat ADHD is Ritalin (the generic form is called methylphenidate), although other stimulant
medications are also used including Adderall, Dexedrine, and Cylert.
Available evidence suggests that stimulants work by correcting a
biochemical condition in the brain that interferes with attention and
impulse control.
What
benefits can stimulant adhd medication produce?
The beneficial effects of stimulant adhd medication
treatment can be dramatic. Attention to class work can improve to the
extent that the child is no longer distinguishable from classmates;
activity level can decline to within normal limits and impulsivity can
be substantially reduced. Even associated difficulties such as
disruptive behavior and peer relationship problems sometimes show
dramatic improvement. Interactions between parent and child and between
the child and his or her siblings have also been shown to improve.
Academically, many children show clear improvements in the quantity and
quality of the work they complete. It remains to be seen, however,
whether these short term changes result in long term gains in
children's academic, behavioral, and social functioning.
How long does
it take stimulant adhd medication to work?
The effects produced by stimulant medication occur
quickly, and parents and teachers often observe an improvement in the
child almost right away. The beneficial effects of stimulant medication
vary in length depending on the child and the type of stimulant, (i.e.
Adderall, Dexedrine, and Cylert last longer than Ritalin) but are
generally gone within 3-8 hours. For this reason, children often
require several doses during the day. "How extensively has the use of
stimulant medication been studied?" The efficacy and safety of
stimulant medication for treating ADHD have been documented in over 150
controlled studies involving children, adolescents, and adults. Despite
the impressive empirical support for stimulant treatment, several
cautions should noted. These include the following:
Most studies have been conducted with school age
children and the available evidence with other age groups is more
limited. Stimulants appear to be quite effective with adolescents but
less helpful with most preschoolers. Available data indicates that many
adults with ADHD will also benefit.
Over 80% of studies done prior to 1997 examined the
efficacy of methylphenidate (the generic name for Ritalin) and few well
controlled studies on other stimulant medications To date, however,
there is little evidence of differential effectiveness for different
stimulants.
Almost all studies are very brief - not more than a few
weeks duration at most - and the magnitude of long term benefits
resulting from stimulant medication treatment are not clearly
documented.
Most studies have been restricted to Caucasian males and
less is known about the efficacy and safety of stimulant medication
with females and minorities. To date, however, there is no reason to
expect substantially different results in these populations.
What
kinds of side effects are associated with stimulant adhd medication?
As with any medication, stimulant adhd medication used
in treating ADHD can produce adverse side effects in some children.
These can include: sleep difficulties, stomach aches, headaches,
appetite reduction, drowsiness, irritability, nervousness, and
excessive staring among others. In rare cases, stimulant medication can
lead to nervous tics, hallucinations, and bizarre behavior.
Learn more about ADHD
drug side effects.
The list of possible side effects can be scary to
parents considering the use of medication for their child, but it is
important to emphasize that the vast majority of children with ADHD
experience no adverse effects. Based on the findings from many
carefully controlled studies, physicians have concluded that when
properly employed stimulant medication is safe and the side effects are
minimal. When side effects do occur they are frequently short lived and
often disappear when the dosage is reduced. Despite these data,
however, it is obviously important for parents to discuss their
questions and concerns with their child's physician.
But I've
heard all kinds of bad things about using Ritalin?
There are a number of myths concerning stimulant
medication that discourage many parents from considering its use for
their child. These myths are summarized in an excellent book titled
Attention Deficit Disorder and Learning Disabilities: Realities, Myths,
and Controversial Treatments by Barbara Ingersoll and Sam Goldstein
(highly recommended) and include the following:
- * Children treated with stimulant medication will
become addicted to it and are more likely to abuse other drugs.
- There is no data which indicates that addiction to
stimulant medication is a problem or that children treated with
stimulants are more likely to abuse other substances.
- * Stimulant medication stunts growth. The available
literature indicates that ultimate height appears to be unaffected if
treatment is discontinued in adolescence. However, there have been no
studies of growth in children treated continually from childhood into
young adulthood so caution here is warranted.
- * Stimulant medication works by turning children into
"zombies". Some children do become sluggish and withdrawn when on
medication, but these symptoms generally indicate that the dose is too
high, or that a co-existing condition such as a mood problem has not
been identified.
- Studies have shown an increase in prosocial behavior
in ADHD children treated with stimulants, which would not be the case
if it simply turned children into "zombies".
***Factors
to consider in deciding on the use of medication***
* What other interventions have already been tried?
Some children with ADHD can have their symptoms
effectively managed via other means including appropriate behavioral
and educational interventions. If you are concerned about using
medication with your child, make sure that non-medical interventions
have been tried first. This is an important issue to discuss with your
child's physician.
* How
much difficulty are the child's adhd symptoms actually creating?
The degree of impairment in academic, social, and
behavioral functioning caused by ADHD can vary substantially. If the
impairment experienced by your child is on the modest side, medication
may not even be necessary.
* What is the child's
attitude towards taking medication?
It is very important to discuss the rational for using
medication with the child. The child needs to know why it is being
suggested and how it can be helpful. This is especially true for older
children and adolescents, who may have concerns about being teased
should their peers find out that they are taking medicine. If children
have strong objections to taking medication, these should be discussed
and understood. Should these objections persist, using medication may
not be productive.
* Will objective information
about the effects of medication be provided?
In my opinion, this is critical. Despite the well
documented benefits of stimulant medication, as many as 20-30% of
children do not experience significant benefits. In addition, many
parents are surprised to learn that when children with ADHD receive
only a placebo (i.e. medication that appears to be the real thing but
is not), teachers frequently report significant improvement in the
child's behavior. This means that some children may receive stimulant
medication for a sustained period even though they derive no objective
benefit from it, or fail to receive the most beneficial dose.
"So how
do I know for sure that the medication I really helping my child?"
Fortunately, it is not hard to conduct a careful trial
that provides more objective information about a child's response to
medication. This is accomplished by having the child receive different
medications doses as well as a placebo over a 3-4 week period. At the
end of each week, the child's teacher completes ratings of the child's
behavior and academic performance. Because neither the child nor the
teacher know what the child was receiving each week during the trial,
the teacher's ratings provide more objective information. By comparing
the ratings made each week one can determine whether:
- * medication was clearly superior to placebo;
- * what dose produced the optimal response;
- * whether any adverse side effects were observed
(sometimes children report what appear to be side effects when they are
only getting a placebo);
- * what problems with behavior and academics may
remain even if medication clearly helped, and which need to be targeted
via other means.
This procedure provides more reliable and objective
information that can be used to decide about the benefits of ongoing
medication use. Unfortunately, many physicians do not gather objective
feedback and rely on anecdotal reports to base medication decision on.